Customers turn to IQsynthesis to identify safer, more economical routes to new drug candidates that reduce waste and optimize the use of pilot plant and manufacturing equipment.

Where applicable, our efforts aim at replacing chromatography with other, less expensive methods of purification or improving yields by eliminating side products.

We save customers the expense of doing process work at high cost GMP manufacturers-whose rates are higher than ours-by improving their processes before they turn to a GMP lab.

As with our custom synthesis services, we carefully document our experimental procedures and analytical methods in our final report to the customer.

Our process development services save customers time and money, as this example shows:

Putting Our Technical Expertise to Work to Save Customers Time and Money

A biotech start-up needed a lead compound on a development track made under GMP. The company also needed 500 g of the compound for pharmaceutical studies and pilot toxicology studies. The company's synthesis used large amounts of class 2 solvents, relied on chromatography in all five steps, was run at very low payloads and included a step with an unpredictable exotherm.

Our staff overhauled the process-increasing the payloads, eliminating class 2 solvents and all but a small fraction of the chromatography and replacing the exothermic step with a controllable one. And in only 10 weeks, we also produced a certified batch of > 700 g, along with a certificate of analysis and a well-documented report with detailed experimentals and full spectral support on the revised process. Our customer then transferred the process-ready for use-to a GMP manufacturer.